Figure 4

Analysis of AMD-associated genes and their overlap with pleiotropic loci. (A) Number of genes, which overlapped with R² loci of trait groups (B) Number of AMD-associated tissues per gene as identified by TWAS and overlap of genes with at least a single R² locus (Mann-Whitney-U-Test P-value 0.0053) (C) Trait groups shared by AMD-associated genes identified in this study (black) and by all predictable genes (grey). The latter have been scaled from in total 24,388 to 106 genes to enable a better comparability. “Other” include “Aging”, “anthropometric traits”, “Blood cells”, “cardiovascular diseases”, “Complex eye diseases and traits”, “Lifestyle”, and “Immune-related traits”. Significance was assessed through a Fisher exact test. *P-value < 0.05; **P-value < 0.01; ***P-value < 0.001.