Table 2 AMD-associated genes located in novel loci that did not reach genome-wide significance in previous GWAS studies2.

From: A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Gene

Chr

Gene Expression Prediction

Strongest effect tissuea

Model Information in Strongest Effect Tissue

Predictable Tissues

AMD associated (FDR < 0.001)

Mean effect size (SD)

Variants in model

AMD associated (GWAS P-value < 1 × 10-04)b

C1orf21

1

15

1

−0.028

Liver

34

3

CD55

1

17

3

−0.016 (0.003)

Esophagus Muscularis

59

5

CR2

1

3

1

−0.013

Muscle Skeletal

40

6

NOSTRIN

2

18

1

−0.015

Esophagus Mucosa

44

0

PPIL3

2

27

16

0.037 (0.004)

Adipose Subcutaneous

37

24

NDUFB3

2

6

4

0.005 (0.001)

Adipose Subcutaneous

12

8

ADAM19

5

21

12

−0.013 (0.006)

Adipose Subcutaneous

25

8

IP6K3

6

17

1

0.019

Cells Transformed fibroblasts

22

1

ZFP37

9

10

1

−0.017

Adipose Subcutaneous

53

0

RP11.777F6.3

11

2

1

0.007

Testis

5

2

CEP57

11

23

3

−0.02 (0.005)

Skin Not Sun Exposed Suprapubic

48

0

AP001877.1

11

24

8

−0.016 (0.006)

Nerve Tibial

50

0

RIN3

14

13

1

0.018

Colon Sigmoid

24

2

ULK3

15

17

1

−0.01

Lung

10

4

USP7

16

3

1

0.014

Muscle Skeletal

55

1

FUT2

19

11

1

−0.009

Lung

23

0

MAMSTR

19

9

1

0.007

Adrenal Gland

13

0

LILRA3

19

23

1

−0.016

Colon Sigmoid

15

2

  1. aTissue, which showed the highest absolute effect size. bNumber of variants in prediction model, which were AMD-associated with a p-value smaller than 1 × 10−04 in Fritsche et al. (2016) (ref. 2). Chr = Chromosome.
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