Figure 3 | Scientific Reports

Figure 3

From: Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models

Figure 3

RNA-sequencing analysis of pancreatic tumour tissues obtained from orthotopic mouse model administered with vactosertib, nal-IRI/5-FU/LV, and the combination. (A) Heatmap plot of DEGs using the hierarchical clustering method. (B) Top 10 pathways characterized by from GO enrichment analysis of DEGs (cutoff of P < 0.001). (C) GO enrichment plot for positive regulation of apoptotic process plotted by Gene Set Enrichment Analysis (GSEA). (D) TUNEL assay of pancreatic tumour tissues used for RNA sequencing. Note that more apoptotic cells were shown in the tumour tissues obtained from mice administered with combination of vactosertib with nal-IRI/5-FU/LV.

Back to article page