Figure 3 | Scientific Reports

Figure 3

From: Maturational delay and asymmetric information flow of brain connectivity in SHR model of ADHD revealed by topological analysis of metabolic networks

Figure 3

Brain network analysis with graph filtration during maturation. The changes in the number of connected components with threshold filtration were shown (A). The sequence of integration of a GCC during filtration was visualized in each group (B). Maturational changes of SLDs between region pairs were shown in the form of SLMs (C). The SLDs between hippocampus-cortical/subcortical pairs of regions were significantly getting closer in the control rats (WKY) during growth (FDR < 0.05) (D). The SLDs between RSC-cortical/subcortical pairs and between left-sided cortices of the ADHD-model rats (SHR_ADHD) were significantly getting closer during growth (FDR < 0.05) (E). Abbreviations: AC, auditory cortex; ADH, anterodorsal hippocampus; F, frontal; FAC, frontal association cortex; FDR, false discovery rate; GCC, giant connected component; HIP, hippocampus; O, occipital; P, parietal; ParA, parietal association cortex; PVH, posteroventral hippocampus; RSC, retrosplenial cortex; SLD, single linkage distance; SLM, single linkage matrix; Ssc, somatosensory cortex; T, Temporal; VC, visual cortex; w. or w.o., weeks old.

Back to article page