Figure 3 | Scientific Reports

Figure 3

From: A semisynthetic borrelidin analogue BN-3b exerts potent antifungal activity against Candida albicans through ROS-mediated oxidative damage

Figure 3

Survival and body weight of immunocompromised mice infected intravenously with C. albicans SC5314 (A) and CGMCC 2.2086 (B). Animals were immunocompromised by intraperitoneal injection of cyclophosphamide (100.0 mg/kg) at 3 days before and 1 day after infection. Fungal suspension (C. albicans: 2 × 105 CFU/mouse) was inoculated into the lateral tail vein of mice, 3 days (72 h) after the intraperitoneal injection of cyclophosphamide. Animals were treated for 5 days with BN-3b (2.0 mg/kg or 4.0 mg/kg), FLC (2.0 mg/kg), AMB (2.0 mg/kg), or vehicle, starting at 24 h after infection. There were 14 animals in each treatment group.

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