Figure 1 | Scientific Reports

Figure 1

From: GluN2A-selective positive allosteric modulator-nalmefene-flumazenil reverses ketamine-fentanyl-dexmedetomidine-induced anesthesia and analgesia in rats

Figure 1

Schematic diagram of the evaluation of anesthesia and the MWM experimental design. (A) The anesthesia time was divided into four intervals. After the rats were anesthetized, antagonists were administered once the righting reflex was lost, and the durations of LORR and analgesia were recorded. (B) Experimental design of the MWM. KFD: combination of 10 mg/kg ketamine, 0.01 mg/kg fentanyl, and 0.1 mg/kg dexmedetomidine; the combination of anesthetics was administered in a single injection. PNF: combination of 2 mg/kg PAM, 0.1 mg/kg nalmefene, and 0.4 mg/kg flumazenil; the PAM was administered i.g. followed by injection of the nalmefene and flumazenil combination. (C) The structure of the PAM (GNE-5729).

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