Figure 2 | Scientific Reports

Figure 2

From: Streamlined selection of cancer antigens for vaccine development through integrative multi-omics and high-content cell imaging

Figure 2

Positive linear correlation between TCR diversity and MHC gene expression. (a) Histologic analysis showing TIL-resident tumors from six patients with TNBC. (b,c) TCR-repertoire analysis showing the number of TCR clonotypes per 10 million reads (b) and the clonality of expanded TCR clones defined as the frequency of the top 10% of TCR clones (c). (d) Comparison of MHC class І expression in tissue samples from each patient. MHC class І expression indicates the total expression of HLA-A, HLA-B, and HLA-C molecules. (e) The relationship between the number of TCRβ clonotypes and the expression of MHC class I genes. Pearson’s correlation was calculated between two groups.

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