Figure 7 | Scientific Reports

Figure 7

From: Synchronization of the circadian clock by time-restricted feeding with progressive increasing calorie intake. Resemblances and differences regarding a sustained hypocaloric restriction

Figure 7

Schematic representation of the effects of HCT and NCT over metabolic homeostasis. Metabolic functions, peripheral clocks, and behaviour are regulated by the feeding. Ketone bodies and free fatty acids (FFAs) as energy sources and signaling molecules. FGF21 as a regulator of metabolism and circadian behaviour. Regardless of the calorie intake and lipid storage, adipose tissue in both TRF conditions performs lipolysis to induce a similar food anticipatory activity (FAA) response. Arrows colour indicates pathways induced by HCT (blue, food access ZT4-ZT6), NCT (orange, food access ZT4-ZT9) or both (black). Triacylglycerol (TAG).

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