Table 3 Lipid mediators in mildly obese nondiabetic subjects compared to morbidly obese subjects adjusted for age.

SPM (ρg/ml)	Mild obesity (n = 15)	Morbid obesity (n = 29)	p value
14-HDHA	36.9 [22.4, 289.6]	483.4 [170.7, 749.1]	0.011
17-HDHA	152.0 [118.1, 298.5]	90.8 [72.1, 139.0]	< 0.001
18-HEPE	67.5 [42.1, 79.0]	40.7 [27.5, 66.7]	0.040
LTB₄	32.5 [19.2, 76.9]	19.6 [0, 72.3]	0.34
LXA₄	0 [0, 0]	0 [0, 0.14]	0.13
LXB₄	0 [0, 0]	0 [0, 2.0]	0.34
MaR1	24.1 [0, 41.3]	9.1 [0, 25.3]	0.69
MaR 2	0 [0, 0]	0 [0, 0]	0.14
PD1	0 [0, 0]	67.6 [55.9, 83.7]	< 0.001
PDX	0 [0, 0]	0 [0, 0]	0.40
PGD₂	4.9 [3.6, 14.8]	4.7 [2.9, 9.1]	0.21
PGE₂	1.7 [0, 27.6]	14.5 [2.6, 49.7]	0.054
RvD1	8.1 [0, 17.4]	5.1 [3.5, 8.8]	0.15
RvD2	0 [0, 0]	0 [0, 0]	0.63
RvD3	0.6 [0, 2.2]	2.4 [1.7, 2.9]	0.036
RvD4	0 [0, 0]	241.3 [144.3, 389.6]	< 0.001
RvD5	0 [0, 0]	0 [0, 0]	0.16
RvE1	0 [0, 0]	0 [0, 0]	0.38

LTB₄ leukotriene B₄, LXA₄ lipoxin A₄, LXB₄ lipoxin B₄, MaR1 maresin 1, MaR2 maresin 2, PD1 protectin D1, PDX protectin X, PGD₂ prostaglandin D₂, PGE₂ prostaglandin E₂, RvD1 resolvin D1, RvD2 resolvin D2, RvD3 resolvin D3, RvD4 resolvin D4, RvD5 resolvin D5, RvE1 resolvin E1, SPM specialized pro-resolving lipid mediators, 14-HDHA 14-hydroxy-docosahexaenoic acid, 17-HDHA 17-hydroxy-docosahexaenoic acid, 18-HEPE 18-hydroxy-eicosapentaenoic acid.

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