Table 6 Pre- and post-surgery characteristics and SPM and eicosanoid levels in diabetic subjects with remission of diabetes (remitters) compared to diabetic subjects without remission of diabetes (non-remitters) after bariatric surgery.

From: The relationship between specialized pro-resolving lipid mediators, morbid obesity and weight loss after bariatric surgery

	Pre-surgery			Post-surgery			Pre vs. Post
	Remitters (n = 8)	Non-remitters (n = 5)	p	Remitters (n = 8)	Non-remitters (n = 5)	p	p^a	p^b	% change in remitters	% change in nonremitters	p^c
Weight (lb)	290.0 ± 43.8	304.9 ± 45.6	0.57	167.6 ± 26.2	175.2 ± 28.4	0.63	< 0.001	< 0.001	− 44.6 ± 6.2	− 46.6 ± 4.2	0.55
BMI^d	51.0 ± 7.6	55.3 ± 6.5	0.32	28.0 ± 4.2	30.5 ± 4.4	0.32	< 0.001	< 0.001	− 44.8 ± 7.2	− 44.9 ± 3.3	0.97
WBC^e	8.62 ± 1.77	8.68 ± 5.67	0.97	6.00 ± 0.93	6.99 ± 2.63	0.35	0.004	0.35	− 30.1[− 43.4, − 15.9]	− 13.4 [− 39.3, 25.1]	0.58
Platelets^f	234 ± 28	287 ± 156	0.36	195 ± 25	292 ± 198	0.19	0.016	0.83	− 21.6 [− 23.8, − 6.3]	− 3.2 [− 17.8, 13.2]	0.062
14 HDHA	439.1 [246.2, 1076.4]	46.5 [33.1, 324.7]	0.019	153.9 [109.6, 988.7]	454.1 [317.6, 1012.0]	0.28	0.58	0.14	− 58.2 [− 86.7, 118.5]	+ 875.7 [225.1, 3076.4]	0.030
MaR1	9.6 [0, 23.0]	8.8 [0, 32.6]	0.94	1.8 [0, 16.6]	0 [0, 2.8]	0.35	0.75	0.11	0 [− 80.8, 10.4]	− 36.9 [− 100.0, 0]	0.35
14 HDHA/MaR1	51.6 ± 93.4	1.7 ± 2.1	0.019	11.1 ± 14.9	45.5 ± 101.6	0.016	0.29	0.39
17 HDHA	103.2 [71.4, 148.6]	81.6 [24.5, 91.5]	0.17	49.2 [40.7, 116.6]	99.3 [45.8, 116.7]	0.62	0.26	0.35	− 52.7 [− 67.9, 53.4]	+ 45.8 5 [− 27.6, 509.2]	0.19
18 HEPE	37.2 [31.4, 49.9]	33.4 [15.6, 105.7]	0.94	29.9 [19.9, 46.0]	35.1 [17.7, 81.6]	0.72	0.48	0.69	− 10.7 [− 63.0, 42.8]	− 46.5 [− 62.9, 318.8]	0.83
LTB₄	21.5 [14.0, 40.1]	0 [0, 89.3]	0.17	12.1 [0, 43.1]	0 [0, 67.2]	0.72	0.89	1.00	+ 100.0 [− 100.0, 23.8]	+ 497.5 [− 100.0]^g	0.89
LXB₄	0 [0, 0]	0 [0, 2.2]	0.35	0.51 [0, 2.7]	2.3 [0, 3.6]	0.44	0.068	0.47
PD1	61.7 [47.7, 84.3]	67.6 [48.8, 83.7]	0.94	64.0 [39.4, 81.5]	52.9 [38.0, 71.5]	0.62	0.89	0.23	+ 7.6 [− 30.0, 41.2]	− 24.8 [− 36.5, 6.2]	0.35
PGD₂	3.2 [2.3, 8.3]	8.7 [3.1, 10.9]	0.44	3.2 [2.5, 13.4]	4.8 [3.8, 8.2]	0.52	0.16	0.50	+ 36.1 [− 12.2, 57.8]	− 37.6 [− 51.4, 109.6]	0.44
PGE₂	18.8 [3.4, 55.4]	3.5 [0, 23.8]	0.22	17.2 [7.4, 30.1]	16.9 [10.5, 111.1]	0.72	0.31	0.14	− 36.4 [− 66.3, 14.8]	+ 378.0 [− 22.2]^g	0.048
RvD1	5.3 [2.8, 9.3]	6.6 [4.0, 8.9]	0.83	7.8 [5.1, 12.7]	6.1 [4.6, 10.8]	1.00	0.40	0.35	+ 80.5 [− 34.8, 331.7]	+ 22.1 [− 6.8, 35.4]	0.44
RvD3	1.8 [1.5, 2.6]	2.5 [1.8, 3.0]	0.35	1.7 [1.4, 2.3]	1.6 [1.3, 3.1]	0.94	0.67	0.69	+ 5.8 [− 16.7, 17.0]	+ 5.1 [− 50.5, 16.2]	0.83
RvD4	221.0 [141.2, 330.5]	343.7 [74.1, 473.2]	0.62	187.9 [105.8, 382.5]	314.3 [150.2, 372.5]	0.72	0.67	0.50	− 11.6 [− 33.7, 73.1]	− 9.3 [− 31.1, − 1.5]	0.81

BMI Body mass index, LTB₄ leukotriene B₄, LXA₄ lipoxin A₄, LXB₄ lipoxin B₄, MaR1 maresin 1, PD1 protectin D1, PGD₂ prostaglandin D₂, PGE₂ prostaglandin E₂, RvD1 resolvin D1, RvD3 resolvin D3, RvD4 resolvin D4, WBC white blood cells 14-HDHA 14-hydroxy-docosahexaenoic acid, 17-HDHA 17-hydroxy-docosahexaenoic acid, 18-HEPE 18-hydroxy-eicosapentaenoic acid.
Continuous variables are presented as mean ± SD or median [interquartile range].
A 2-sided p value ≤ 0.05 was considered statistically significant.
^ap value comparing pre- to post-surgery values in remitters using Wilcoxon signed Rank test.
^bp value comparing pre- to post-surgery values in non-remitters using Wilcoxon signed Rank test.
^cp value comparing % change in remitters to non-remitters.
^dBMI expressed as kg/m².
^eWBC expressed as 10⁹ cells/l.
^fPlatelets expressed as cells/µl.
^g75th quartile could not be calculated due to only three evaluable individuals.

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Table 6 Pre- and post-surgery characteristics and SPM and eicosanoid levels in diabetic subjects with remission of diabetes (remitters) compared to diabetic subjects without remission of diabetes (non-remitters) after bariatric surgery.

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