Figure 8
From: Orexin system is expressed in avian liver and regulates hepatic lipogenesis via ERK1/2 activation
Orexins activate ERK1/2 signaling cascade in chicken liver. Intraperitoneal administration of recombinant orexins increased p-ERK1/2Thr202/Tyr204 levels, but not that of p-P38Thr180/Tyr182 or p-JNK1/2Thr183/Tyr185 in chicken liver as demonstrated by Western blot analyses (a–c). The relative expression of MAPK genes was measured by qPCR (d,e). Data are presented as mean ± SEM (n = 12 birds/group). *Indicates significant difference from controls at P < 0.05; ERK extracellular signal-regulated kinase, JNK c-Jun N-terminal kinase, P38 P38 mitogen-activated. Full-length blots/gels are presented in Supplementary Fig. S1.
