Figure 3

Additive survival analysis of 6 candidate miRNAs. (A) The hazard ratios (HR) of each of the miRNA combinations were calculated by additive survival analysis, as shown by the boxplots with dotplots overlaid. The X-axis indicates the number of miRNAs combined; the Y-axis indicates the log2 transformation of the hazard ratio. The red spot indicates the combination of miR-216b-5p, miR-585-5p, and miR-7641. (B) Survival analysis of the combination of the 3 miRNAs shows a significant difference between the all-high and all-low expression groups with log-rank p-value < 0.05.