Figure 3
From: MiR-571 affects the development and progression of liver fibrosis by regulating the Notch3 pathway
Effect of Notch3 signaling on expression of profibrogenic factors. (A) Differences in mRNA expression of Notch3 and profibrogenic factors; (B, C) Differential expression of Notch3 and profibrogenic factor; (D) Effect of Notch3 on TGF-β1 and Smad3 mRNA expression. (E, F) Effect of Notch3 on TGF-β1 and Smad3 protein expression. Recombinant Notch3 was used to induce Notch3 signaling and Notch3 short interference (si) RNA was used to downregulate Notch3 expression, respectively. The mRNA and protein expressions of the receptor Jagged1 and the pro-fibrinogen were up-regulated after Notch3 up-regulation, and the mRNA and protein expressions of the receptor Jagged1 and the pro-fibrinogen were down-regulated after Notch3 down-regulation. *P < 0.05, **P < 0.01.
