Figure 4 | Scientific Reports

Figure 4

From: A SPRY1 ___domain cardiac ryanodine receptor variant associated with short-coupled torsade de pointes

Figure 4

RyR2-I784F effect on caffeine-induced Ca2+ release. The Ca2+ store content was estimated by measuring the amplitude of caffeine (10 mM) induced Ca2+ release from oscillating cells in presence of 0.5 mM of Ca2+. (a) Graphical representation of the average from all cells. (b) Representative plots of one cell. The total number of cells from six separate experiments were for WT n = 1578 and for I784F n = 1760; and after cAMP for WT n = 957 and for I784F n = 1007. ***p < 0.0001 for WT-RyR2 vs RyR2-I784F; †††p < 0.0001 for basal conditions vs after cAMP treatment.

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