Figure 4
From: Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis
Apelin overexpression increases tumor cell proliferation in lung metastases, which can be attenuated by MM54. (A–C) Representative images of lung metastases from a mouse injected with B16 Ap and B16 Mock cells. BrdU-positive cells were visualized with 3-amino-9-ethylcarbazole (AEC) peroxidase substrate solution. (D) Apelin overexpression significantly increased the number of BrdU-positive tumor cells in B16 lung metastases, and this effect was significantly attenuated by APJ receptor antagonist MM54. *p < 0.05.
