Figure 4 | Scientific Reports

Figure 4

From: Associations of pathological diagnosis and genetic abnormalities in meningiomas with the embryological origins of the meninges

Figure 4

Distribution of genetic mutations among different pathological diagnosis. (A) The number of patients harboring mutations for each pathological diagnosis. (B) Comparison of the ratio of patients harboring AKT1, KLF4, SMO, or POLR2A mutations between WHO grade I and WHO grade II tumors. The ratio of patients harboring AKT1, KLF4, SMO, or POLR2A mutations was significantly higher for WHO grade I than for WHO grade II tumors (p < 0.05, significant on the chi-square test with Bonferroni correction). (C) Comparison of the ratio of patients harboring AKT1, KLF4, SMO, or POLR2A mutations between meningothelial meningioma and other pathologies. The ratio of patients harboring AKT1, KLF4, SMO, or POLR2A mutations was higher for meningothelial meningioma than for other pathologies (p < 0.01, significant on the chi-square test with Bonferroni correction).

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