Figure 8

Flow diagram of practical strategy using biomarkers for diagnosing BA and prognosing post-KPE clinical outcomes. Abbreviations: MMP-7, matrix metallopeptidase-7; IL, interleukin; GGT, γ-glutamyl transferase; HA, hyaluronic acid; APRi, aspartate aminotransferase to platelet ratio index; M2BPGi, Mac-2-binding protein glycosylation isomer. Selecting the best cut-off value is based on the largest AUC. The cut-off value is not presented in the investigations of serum IL-18 for diagnosing BA and prognosing post-KPE persistent jaundice and serum HA for prognosing post-KPE significant fibrosis. The best cut-off values of MMP-7 for diagnosing BA and prognosing post-KPE significant liver fibrosis both are 52.85 ng/mL with the largest AUC of 0.99⁵⁸; the best cut-off value of IL-33 for diagnosing BA is 20.8 pg/mL with the largest AUC of 0.995⁵⁶; the best cut-off value of GGT for diagnosing BA is 300 U/L with the largest AUC of 0.9⁶⁰; the best cut-off value of APRi for prognosing liver fibrosis and cirrhosis is 0.88 with the largest AUC of 0.88⁶².