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GPNMB expression in patients with triple-negative breast cancer (TNBC) is a predictor of breast cancer recurrence. (A) Representative immunohistochemistry pattern of GPNMB intensity graded as 0, negative-staining; 1 + , weak; 2 + , moderate and 3 + , strong. (B) Immunohistochemistry showing the GPNMB staining intensity among patients with TNBC. (C) Quantitative expression of GPNMB was compared in TNBC and non-TNBC groups. T test, **P < 0.01. (D) Quantitative expression of GPNMB was compared in immunohistochemical subtypes. (E–H) Kaplan–Meier analysis of the influence of GPNMB protein expression on (E) Overall survival, OS, P = 0.057. (F) Recurrence-free survival, RFS, P = 0.011. (G) Local recurrence-free survival, LRFS, P = 0.056. (H) Distant metastasis-free survival, DMFS, P = 0.020.