Figure 4 | Scientific Reports

Figure 4

From: Lipidated PrRP31 metabolites are long acting dual GPR10 and NPFF2 receptor agonists with potent body weight lowering effect

Figure 4

Lipidated metabolites of GUB03385 robustly reduce body weight and food intake in DIO mice. Effect of subchronic treatment (days 0–6) with GUB08248, GUB08251, GUB10194 and GUB10195 followed by 7-day wash-out period (days 7–13, marked in grey). In vivo efficacy was compared to semaglutide (10 nmol/kg, SC, QD, n = 8). (a) Body weight. (b) 24 h food intake. (c) Total food intake during treatment phase. (d) Total food intake during wash-out phase. (e) Plasma peptide concentrations as measured 4 h after last dosing (treatment day 6). PrRP31 analogues were administered (SC, BID) at a dose of 1,250 nmol/kg (n = 7–8 per group). *p < 0.05, ***p < 0.001 compared to vehicle.

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