Figure 1 | Scientific Reports

Figure 1

From: Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli

Figure 1

Time-kill experiments for the PB-resistant Klebsiella pneumoniae strains (A) C9, (B) L8, (C) L28, and (D) L29. Strains were inoculated on Mueller Hinton broth containing either PB alone or in combination with CBD (2 or 4 µg/mL). A control group was grown in the absence of any drug. At time points 0, 1, 2, 4, and 6 h, an aliquot was removed, and number of cells was determined by inoculating on solid medium and counting colony forming units. The initial time point of each treatment was used as normalization factor. Values represent mean and error bars are standard deviation of the mean from three independent experiments. Asterisks indicate that means are statistically different from the corresponding control group (P < 0.05). PB: polymyxin B; CBD: cannabidiol; MEAC: minimal effective antibiotic concentration.

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