Figure 9
From: Mechanistic insights of ABC importer HutCD involved in heme internalization by Vibrio cholerae
Proposed reaction mechanism. Involvement of TM4–TM5 loop in ATP hydrolysis causes cytoplasmic gate opening (IF state) easing heme release to the inter-dimeric pocket. Heme release to cytoplasm takes place in the absence of ATP. Formation of occluded state constricts the pocket and releases heme.
