Figure 2
From: Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup
Clinical presentation of 12q-amplified tumors. (A,B) CT images of patient 45R1 showing a large primary NB tumor adjacent the upper part of the right kidney and (C) metastases of the lungs as indicated by arrows. (D,E) Corresponding images of a Wilms’ tumor with comparable growth pattern in a child at the similar age. Hematoxylin–eosin staining showing: (F) conventional poorly differentiated neuroblastoma with uniform nuclei and incipient resetting, patient 17E2, (G) large cell neuroblastoma with partly spindling cells and atypical mitoses, patient 45R1 and (H) undifferentiated large and anaplastic cell neuroblastoma with coarse nuclear chromatin, prominent nucleoli and atypical mitoses, patient 38R3. (I) Kaplan–Meier overall survival analysis show upon poor outcome among NB patients with 12q amplification in comparison to NB patients of different genomic subgroups.
