Figure 1
From: BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation
BMP2 is highly expressed in lung adenocarcinoma patients with lymph node metastasis. (A) The representative BMP2 immunohistochemistry (IHC) images in tissue samples from patients with and without lymph node metastasis. Slides were observed under 4 × and 40 × magnification. (B) BMP2 IHC was analyzed in samples derived from 94 patients with lung cancer. Significance was determined by Fisher’s exact test (p = 0.025). (C) Representative images of BMP2 and Vimentin immunofluorescence in samples derived from patients with and without lymph node metastasis. Slides were observed under 10 × magnification. (D) Quantitative analysis of fluorescence intensity of BMP2 and Vimentin. Analysis of fluorescence intensity was done at the original magnification using ImageJ software. At least three fields were quantified.
