Figure 2
From: Linear epitope mapping of the humoral response against SARS-CoV-2 in two independent African cohorts
3D structure of the Spike, Nucleocapsid, and membrane proteins with locations of specific immunodominant epitopes. For all proteins, the blue spheres marked the N-Term extremity of the protein, black ones the C-term extremity, small light blue spheres indicated the main mutations found in SARS-CoV-2 variants described by WHO, small red spheres shown deletions, green spheres marked insertions, and the yellow segments corresponded to the immunodominant peptides found in our study (peptides marked in bold in Table 2). (A) The membrane protein with peptides M002 and M003 recognized by IgM. (B) The nucleocapsid protein with peptides N041, N056, N099 and N100 recognized by IgG and peptide N064 recognized by IgM. (C) Spike with peptides S139, S140, S204 and S287 recognized by IgG. RBD and NTD domains are represented in black and pink respectively. The main mutations in Spike are found in RBD and NTD. (D) representation of the spike protein with the neutralizing epitopes identified in previous epitope-mapping studies1,5,6 which are marked in green.
