Figure 12 | Scientific Reports

Figure 12

From: Identification and validation of oxidative stress and immune-related hub genes in Alzheimer’s disease through bioinformatics analysis

Figure 12

(A) Drug–gene interaction diagram. Green circle indicated the related diagnostic gene and pourpre ellipse indicated the drug. A total of 76 candidate drugs for AD treatment were identified by using DGIdb database. (B) Potential miRNAs regulatory networks. The interaction network consisted of 9 diagnostic genes and 152 miRNAs. The top three hub genes were NEFL (modulated by 79 miRNAs), CNR1 (modulated by 22 miRNAs), and GAD1 (modulated by 17 miRNAs). (C) Potential TFs regulatory networks. The interaction network consisted of 9 diagnostic genes and 91 TFs. The top three hub genes were CNR1 (modulated by 19 TFs), GAD1 (modulated by 13 TFs), and GAP43 (modulated by 12 TFs). GATA2, FOXC1, and CREB1 shared the closest interactions with the diagnostic genes.

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