Figure 3
Bioinformatics analysis identified differentially expressed proteins and enriched pathways. (A) Drug vs con differentially expressed proteins (DEGs-1), red dots are significantly down-regulated and blue dots are significantly up-regulated. (B) KEGG pathways Top20 (DEGs-1), (C) KN-93 vs drug differentially expressed proteins (DEGs-2), red dots are significantly down-regulated and blue dots are significantly up-regulated. (D) Drug vs con upregulation of differential proteins in common with KN-93 group vs drug downregulation of differential proteins, presented in a Venn diagram. DEGs-1 upregulation in common with DEGs-2 downregulation, presented in a Venn diagram. (E) Common proteins of Drug vs con down-regulated differential proteins with KN-93 group vs drug up-regulated differential proteins, presented in a Wayne diagram. (F) Includes 9 samples with 3 replicates per group, grouped into con, drug, and KN-93 groups. Each row in the heat map represents a protein whose expression is normalized across columns, with high expression shown in red and low expression shown in blue. (G) Protein interaction map of 39 proteins with CaMKIIδ.
