Figure 4 | Scientific Reports

Figure 4

From: Breviscapine regulates the proliferation, migration, invasion, and apoptosis of colorectal cancer cells via the PI3K/AKT pathway

Figure 4

Breviscapine regulated cell proliferation and apoptosis through affecting the PI3K/AKT pathway. (A) The protein expression of p-PI3K, PI3K, p-AKT, and AKT were examined through a western blot with different breviscapine concentrations (0, 25, 50, and 100 μM). (B) The protein expression of p-PI3K, PI3K, p-AKT, and AKT was assessed through a western blot at 100 μM breviscapine, and 100 μM breviscapine + 740Y-P groups. *p < 0.05, **p < 0.01, ***p < 0.001 versus control; ##p < 0.01, ###p < 0.001 versus 100 μM breviscapine. (C) The cell viability was measured through CCK-8 assay at concentrations of 100 μM breviscapine and 100 μM breviscapine + 740Y-P groups. (D) Apoptosis was examined through flow cytometry at 100 μM breviscapine and 100 μM breviscapine + 740Y-P groups.

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