Figure 5

Breviscapine suppressed cell migration, invasion and EMT progress through affecting the PI3K/AKT pathway. (A–C) The cell migration and invasion were assessed through transwell and wound-healing assays at 100 μM breviscapine and 100 μM breviscapine + 740Y-P groups. (D) The protein expression of E-cadherin and N-cadherin was evaluated through western blot at 100 μM breviscapine and 100 μM breviscapine + 740Y-P groups. ***p < 0.001 versus control; ##p < 0.01, ###p < 0.001 versus 100 μM breviscapine.