Figure 3

Apigenin attenuates inflammatory cytokines and alleviates atherosclerosis in HFD-fed Ldlr^−/− mice. A and B. IL-1β and IL-18 levels were measured by ELISA within aortas. C and D. Representative en face images of Oil Red O-stained aorta and quantification of lesion area. E and F. Representative aortic root sections stained with Oil Red O, and quantification of aortic lesion areas. G. Representative F4/80 immunostaining and quantification of aortic sinus lesions. Data are presented as the mean ± SEM, ^*P < 0.05, ^**P < 0.01 for HFD mice versus CD mice. ^#P < 0.05, ^##P < 0.01 for HFD mice versus HFD + APN 50 mice.