Table 2 Rare coding variations (n = 38) of WFS1 in patients with early-onset type 2 diabetes.

Position	Region	Codon change	AA change	ACMG*	Allele frequency
Position	Region	Codon change	AA change	ACMG*	1000 Genomes	ExAC
6,303,126	Exon8	TGGTGTGCTTCATGT-T	L535Lfs*3	P	0	0
6,303,589	Exon8	CTGCAGCCACC-C	L689Lfs*18	P	0	0
6,303,602	Exon8	GA-G	E694Gfs*16	P	0	0
6,290,799	Exon4	GCG-GTG	A134V	LP	0	0
6,293,030	Exon5	CAAG-C	K193del	LP	0	0
6,303,407	Exon8	CGG-TGG	R629W	LP	0	0
6,279,355	Exon2	GCG-GTG	A58V	US	0	0.0007
6,279,382	Exon2	CAT-CTT	H67L	US	0	0
6,290,847	Exon4	GCG-GTG	A150V	US	0.005	0.00124
6,292,998	Exon5	GCA-ACA	A179T	US	0	0.00008
6,293,076	Exon5	GGC-AGC	G205S	US	0	0.00012
6,296,873	Exon7	GAG-GCG	E273A	US	0	0.00032
6,302,413	Exon8	ATG-ATA	M297I	US	0	0
6,302,626	Exon8	AGC-AGG	S368R	US	0	0
6,302,741	Exon8	CAT-TAT	H407Y	US	0	0
6,302,756	Exon8	GTC-CTC	V412L	US	0.002	0
6,302,816	Exon8	CTG-GTG	L432V	US	0	0
6,302,927	Exon8	TCG-ACG	S469T	US	0	0
6,302,937	Exon8	CCC-CTC	P472L	US	0	0
6,303,029	Exon8	GTC-ATC	V503I	US	0.002	0.00016
6,303,030	Exon8	GTC-GGC	V503G	US	0	0.00016
6,303,060	Exon8	TAT-TGT	Y513C	US	0	0
6,303,062	Exon8	CTC-TTC	L514F	US	0	0
6,303,197	Exon8	GCC-ACC	A559T	US	0	0.00223
6,303,203	Exon8	ATC-GTC	I561V	US	0	0.00012
6,303,246	Exon8	GCC-GGC	A575G	US	0	0
6,303,368	Exon8	GCC-TCC	A616S	US	0.001	0.00004
6,303,378	Exon8	TCT-TTT	S619F	US	0	0
6,303,479	Exon8	CGC-TGC	R653C	US	0	0.00078
6,303,491	Exon8	ATG-TTG	M657L	US	0	0
6,303,575	Exon8	CGC-TGC	R685C	US	0	0.00036
6,303,644	Exon8	CGC-TGC	R708C	US	0	0.00008
6,303,869	Exon8	TTC-CTC	F783L	US	0	0.00028
6,303,891	Exon8	TCG-TTG	S790L	US	0	0
6,303,936	Exon8	CGG-CAG	R805Q	US	0	0.00008
6,304,086	Exon8	TCA-TTA	S855L	US	0	0.00008
6,304,097	Exon8	CGG-TGG	R859W	US	0	0.00016
6,304,134	Exon8	GTG-GGG	V871G	US	0	0.00044

RefSeq: NP_005996.2, AA change amino acid change, 1000 Genomes 1000 Genomes Project-East Asian, ExAC exome aggregation consortium database-East Asian.
*The classification of rare coding variants according to the guideline of the American College of Medical Genetics and Genomics. Evidences of pathogenicity was detailed in Supplementary Table 1. P pathogenic, LP likely pathogenic, US uncertain significance.

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