Figure 4 | Scientific Reports

Figure 4

From: Hypertrophic cardiomyopathy in purpose-bred cats with the A31P mutation in cardiac myosin binding protein-C

Figure 4

Echocardiography and gross pathology of a severe HCM-affected cat homozygous for the MYBPC3 A31P mutation (cat #2011-14). (A) M-mode image of the LV taken from the right parasternal short axis imaging plane documenting severe LV hypertrophy in a female cat at 3.5 years of age. (B) A coin-cut gross pathology image of LV showing severe wall thickening and prominent papillary muscles; white bar = 1 cm. (C) Longitudinal echocardiographic data of the LVPWd from the right parasternal short axis imaging plane over sequential evaluations. (D) Longitudinal echocardiographic data of LA/Ao in 2D from the right parasternal short axis imaging plane over sequential evaluations. The final evaluation in C and D was completed at ~ 3.5 years of age, immediately prior to euthanasia for new onset left-sided congestive heart failure. Dotted red lines (C) & (D) represent the threshold for LVPWd measures consistent with HCM and LA/Ao consistent with LA enlargement. HCM: hypertrophic cardiomyopathy; MYBPC3: myosin-binding protein-C; LV: left ventricle; LVPWd: left ventricle posterior wall in diastole; LA/Ao: left atrium to aortic root ratio; LA: left atrium.

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