Figure 1 | Scientific Reports

Figure 1

From: Cytoskeletal disarray increases arrhythmogenic vulnerability during sympathetic stimulation in a model of hypertrophic cardiomyopathy

Figure 1

Representative electrocardiograms (ECG) before (A–B) during (C–D) and 2 h after (E–F) i. p. injection of 2 × 20 mg/kg ISO in a wt (A, C, E) and a αMHC403/+ mouse (B, D, F). Signal-averaged complexes show distinct effects of ISO on wt (G) and αMHC403/+ mouse (H). Representative ECG recordings in an αMHC403/+ mouse before (I) and after 1 mg/kg atenolol (J) and following ISO (K) treatment. (L) Recovery of the αMHC403/+ mouse 2 h post-ISO. (M–O) R–R intervals plotted against time for ISO treated wt (M), αMHC403/+ mouse (N) and αMHC403/+ mouse treated with atenolol (Ate) 10 min prior to ISO as indicated (O). The irregular RR intervals representing arrhythmias can be seen as dots following ISO.

Back to article page