Figure 4

(A) Average composite histopathology scores for inflammation, necrosis, hemorrhage, edema, and fibrosis assessed by H&E stain of skin sections at injection site between BSR and EXR versus intra-animal saline controls at acute (24 h post-administration) and chronic (10 day post-administration) time points after drug administration. (B) Average fibrosis scores assessed by trichrome histological stain of skin sections at injection site between BSR and EXR versus intra-animal saline controls at chronic (10 day) time point after drug administration. **P-value < 0.01; ns, not significant.