Figure 6 | Scientific Reports

Figure 6

From: Evaluation and comparison of pharmacokinetic profiles and safety of two extended-release buprenorphine formulations in common marmosets (Callithrix jacchus)

Figure 6

Representative H&E histology images of skin injection site sections. BSR site at chronic time point under 4 × (A) and 20 × (B) magnification depicts disruption of the deep dermis (black star) and hypodermis by necrosis/inflammation (red arrows) and multiple clear distended spaces (black arrows) associated with injected material (red star). EXR site at chronic time point under 4 × (C) and 20 × magnification (D) shows disruption of deep dermis/hypodermis (black star) and underlying musculature (yellow stars) due to necrosis/inflammation (red arrows), and multiple clear needle-shaped crystals (cholesterol clefts) (black arrows) and variably shaped distended spaces (yellow stars) are associated with injected material (red stars). An epithelioid cap (red arrows) surrounding injected material and multinucleated cells (green arrows) are also frequent (D).

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