Figure 1
From: Non-invasive enhancement of intracortical solute clearance using transcranial focused ultrasound
Transport of intracortical fluorescence tracers. (a) The schematic illustration of animal experimental procedures (start time = 0 min with respect to the needle insertion). Blue cone illustrates the acoustic beam profile from the FUS transducer. (b) Illustration of the ultrasound pulsing scheme. (c) The acoustic pressure profile along the longitudinal axis to the sonication (left) and the transverse plane at the focus (right). The arrow indicates the sonication direction. An acoustic focal profile bound at full-width-at-90%-maximum pressure (FW90%M) is shown by the white dotted line and the profile of full-width-at-half-maximum (FWHM) pressure is shown by the black dotted line (bar = 10 mm). (d) Exemplary OA and FITC-d distributions from a rat. 0 mm in the x-axis denotes the injection site while positive direction of the axis indicates rostral direction. (e) Slice-specific volume distributions of OA and (f) FITC-d tracer. The shaded areas represent the slices showing a significant difference (P < 0.05) between the FUS + and FUS− conditions (n = 7 each). Error bar: standard error of the mean (SEM).
