Figure 3

The changes in E/e′ from baseline to 48 weeks stratified by the potential influential factors. The statistical analyses of absolute changes in each parameter from baseline to 48 weeks were performed using analysis of covariance adjusted for the baseline data. LSM, 95% CI and p values were calculated from the analysis of covariance model. The LSM difference (3.0 ± 0.5, 95% CI − 8.34 to 14.21) in the patients with LVEF < 50% was omitted because the 95% CI was large due to small sample size. BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, E/e′ ratio the peak early diastolic transmitral flow velocity (E) to peak early diastolic mitral annulus velocity (e′), eGFR estimated glomerular filtration rate, NYHA New York Heart Association, LVEF left ventricular ejection fraction, LSM least-squares mean, CI confidence interval.