Figure 9 | Scientific Reports

Figure 9

From: Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis

Figure 9

The knockdown of Nrf2 promoted oxaliplatin-induced pyroptosis in vitro. (A–D) By western blot, the results revealed that oxaliplatin raised the expression of GSDME-N. Compared with the control group, after knocking down Nrf2, oxaliplatin increased the expression of GSDME-N. (E–J) The knockdown of Nrf2 enhanced the increase IL-1β, TNF-α, and LDH release caused by oxaliplatin. (K)The schematic installation. Data are shown as the mean ± SD, **p < 0.01; ***p < 0.001.

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