Figure 8 | Scientific Reports

Figure 8

From: Identification of endoplasmic reticulum stress-related signature characterizes the tumor microenvironment and predicts prognosis in lung adenocarcinoma

Figure 8

Dissecting the immune landscape interplay with endoplasmic reticulum stress-related signatures. (A, B) Comparative evaluation of ImmuneScore and TumorPurity metrics using the ESTIMATE algorithm, highlighting discrepancies between high- and low-risk groups. (C–E) Correlation plots showcasing the nuanced association between Risk scores and metrics of immune cell abundance or infiltration, as decoded by the ESTIMATE, EPIC, and TIMER algorithms. These plots accentuate the intricate ties between risk scores and the immunological realm. (F) A visual representation of the differential abundance of 10 pivotal immune cell types across the High- and Low- risk cohorts, deduced using the MCPCounter algorithm. This juxtaposition underscores the potential immunosuppressive tendencies of the high-risk group. (G) Relationship between Risk scores and abundance between 24 immune cell types.

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