Figure 3

Immune response characteristics between two distinct IR patterns. (A) GSVA enrichment analysis showing the activation of immune pathways in distinct IR patterns in the training cohort. The heatmap was used to visualize the enrichment differences of these processes between the two IR patterns, where red represents activated pathways and blue represents inhibited pathways. (B) Heatmap of antiviral innate immune response pathway DEGs between the two IR clusters in the training cohort. Red represents high expression levels, and blue represents low expression levels. The IR cluster was used for patient annotations. Each column represents one patient and each row represents one gene associated with the innate immune signaling pathway. (C) Expression levels of MHC-related genes between the two IR clusters in the training cohort (Mann–Whitney U test). (D) The abundance of immune cells calculated by CIBERSORT between distinct IR patterns in the training cohort (Mann–Whitney U test). (E) The abundance of immune cells calculated by xCell between distinct IR patterns in the training cohort (Mann–Whitney U test). Asterisks represent the statistical P value (*P < 0.05; **P < 0.01; ***P < 0.001; ns no significance).