Table 4 Adjusted odds ratios for respiratory outcomes before NICU discharge among very low birth weight infants received different courses and duration of mechanical ventilation when considering the interaction effect.

From: Effect of different courses and durations of invasive mechanical ventilation on respiratory outcomes in very low birth weight infants

Outcome

Number of mechanical ventilation courses

Duration of mechanical ventilation

Interaction term#

1 course

2 courses

 ≥ 3 courses

 ≤ 7d

8-21d

22-35d

 ≥ 36d

p-value

BPD

Reference

1.45 (0.96, 2.19)

0.53 (0.06, 4.62)

Reference

2.11 (1.64, 2.72)

4.84 (3.17, 7.39)

15.27 (8.01, 29.12)

0.5864

Severe BPD

Reference

10.27 (2.19, 48.22)

N/A*

Reference

8.29 (1.98, 34.66)

67.85 (16.51, 278.86)

982.79 (249.24, > 999.999)

0.0838

Death

Reference

1.59 (0.64, 3.98)

11.08 (1.84, 66.57)

Reference

0.97 (0.42, 2.24)

8.21 (3.95, 17.09)

7.07 (2.98, 16.78)

0.0172

Requirement of home oxygen therapy

Reference

1.07 (0.63, 1.81)

38.74 (4.42, 339.64)

Reference

1.76 (1.30, 2.38)

4.22 (2.70, 6.58)

5.39 (3.12, 9.34)

0.0382

Discharged with requirement of non-invasive/invasive mechanical ventilation

Reference

0.94 (0.32, 2.77)

13.12 (1.78, 96.40)

Reference

1.23 (0.61, 2.50)

7.55 (3.77, 15.12)

3.99 (1.65, 9.65)

0.1438

  1. Adjusted for gestational age, birth weight, sex, small for gestational age, 5-min Apgar score, treatment with surfactant, DART treatment, PDA, NEC, sepsis, mechanical ventilation duration (analyzed as grouping variable), and mechanical ventilation courses (analyzed as grouping variable). *N/A: Not Applicable. No valid statistical result was found because of the limited number of valid events. # Interaction term here refers to invasive MV duration*invasive MV course.
Back to article page