Table 1 ENIGMA MDD participating cohorts in the study. Each cohort is presented with number of total subjects, number of patients with major depressive disorder (MDD) and healthy controls (HC), as well as their mean age (in years) and sex (number and % of females).

AFFDIS

 Total

79

39.75 (14.67)

36 (46)

 HC

46

39.87 (14.29)

22 (48)

 MDD

33

39.58 (15.18)

14 (42)

Pharmo (AMC)

 Total

51

29.37 (4.64)

51 (100)

 HC

0

N/A

N/A

 MDD

51

29.37 (4.64)

51 (100)

Barcelona-StPau

 Total

94

46.66 (7.81)

72 (77)

 HC

32

46.03 (8.00)

23 (72)

 MDD

62

46.98 (7.68)

49 (79)

CARDIFF

 Total

40

46.55 (11.74)

27 (68)

 HC

0

N/A

N/A

 MDD

40

46.55 (11.74)

27 (68)

CSAN

 Total

109

34.70 (12.88)

74 (68)

 HC

49

33.20 (12.07)

34 (69)

 MDD

60

35.92 (13.38)

40 (67)

Calgary

 Total

107

17.03 (4.12)

60 (56)

 HC

52

15.81 (5.03)

29 (56)

 MDD

55

18.19 (2.51)

31 (56)

DCHS

 Total

79

30.91 (6.71)

79 (100)

 HC

61

31.49 (6.82)

61 (100)

 MDD

18

28.94 (5.89)

18 (100)

ETPB

 Total

60

35.03 (9.86)

36 (60)

 HC

26

33.88 (10.22)

16 (62)

 MDD

34

35.91 (9.48)

20 (59)

Episca (Leiden)

 Total

49

15.00 (1.54)

42 (86)

 HC

30

14.73 (1.53)

26 (87)

 MDD

19

15.42(1.46)

16 (84)

FIDMAG

 Total

69

47.22 (12.29)

44 (64)

 HC

34

45.94 (11.49)

22 (65)

 MDD

35

48.46 (12.90)

22 (63)

Groningen

 Total

41

44.27 (13.67)

30 (73)

 HC

21

44.05 (13.96)

16 (76)

 MDD

20

44.50 (13.34)

14 (70)

Houston

 Total

290

28.72 (16.30)

169 (58)

 HC

186

26.76 (15.91)

105 (56)

 MDD

104

32.23 (16.39)

64 (62)

Jena

 Total

107

46.76 (15.00)

52 (49)

 HC

77

47.75 (15.93)

36 (47)

 MDD

30

44.20 (11.92)

16 (53)

LOND

 Total

130

49.67 (8.62)

79 (61)

 HC

61

51.72(7.87)

32 (53)

 MDD

69

47.86(8.85)

47 (68)

MODECT

 Total

42

72.71 (9.25)

28 (67)

 HC

0

N/A

N/A

 MDD

42

72.71 (9.25)

28 (67)

MPIP

 Total

548

48.66 (13.59)

315 (57)

 HC

211

49.53 (13.02)

124 (59)

 MDD

337

48.12 (13.90)

191 (57)

Melbourne

 Total

245

19.42 (2.88)

130 (53)

 HC

102

19.58 (2.97)

54 (53)

 MDD

143

13.31 (2.80)

76 (53)

Minnesota

 Total

110

15.47 (1.89)

79 (72)

 HC

40

15.68 (1.98)

26 (65)

 MDD

70

15.36 (1.83)

53 (76)

Moraldilemma

 Total

70

18.81 (1.94)

70 (100)

 HC

46

18.50 (1.75)

46 (100)

 MDD

24

19.42 (2.14)

24 (100)

NESDA

 Total

219

38.11 (10.32)

145 (66)

 HC

65

40.29 (9.67)

42 (65)

 MDD

154

37.19 (10.45)

103 (67)

QTIM

 Total

386

22.08 (3.25)

267 (69)

 HC

284

22.11 (3.30)

190 (67)

 MDD

102

22.01 (3.11)

77 (75)

UCSF

 Total

163

15.46 (1.31)

91 (56)

 HC

88

15.32 (1.28)

42 (48)

 MDD

75

15.63 (1.33)

49 (65)

SHIP_S2

 Total

579

55.01 (12.57)

294 (51)

 HC

443

55.44 (12.80)

198 (45)

 MDD

136

53.59 (11.68)

96 (71)

SHIP_T0

 Total

1229

50.15 (13.69)

607 (49)

 HC

919

50.50 (14.18)

405 (44)

 MDD

310

49.12 (12.04)

202 (65)

SanRaffaele

 Total

45

49.07 (13.51)

32 (71)

 HC

0

N/A

N/A

 MDD

45

49.07 (13.51)

32 (71)

Singapore

 Total

38

39.50 (6.43)

18 (47)

 HC

16

38.69 (4.59)

8(50)

 MDD

22

40.09 (7.43)

10 (45)

Socat_dep

 Total

179

37.85 (13.34)

161 (90)

 HC

100

36.42 (13.57)

90 (90)

 MDD

79

39.66 (12.81)

71 (90)

StanfFAA

 Total

32

32.71 (9.56)

32 (100)

 HC

18

30.44 (9.96)

18 (100)

 MDD

14

35.63 (8.14)

14 (100)

StanfT1wAggr

 Total

115

37.18 (10.27)

69 (60)

 HC

59

37.24 (10.43)

36 (61)

 MDD

56

37.11 (10.09)

33 (59)

TIGER

 Total

60

15.63 (1.34)

38 (63)

 HC

11

15.18 (1.03)

5 (45)

 MDD

49

15.73 (1.38)

33 (67)

All sites

 Total

5365

39.84 (17.69)

3227 (60)

 HC

3077

40.82(18.09)

1706 (55)

 MDD

2288

38.52 (17.05)

1521 (66)