Table 4 Association of COVID-19 risk variants with rapid deterioration in CXR findings.

From: Characteristics of patients with COVID-19 who have deteriorating chest X-ray findings within 48 h: a retrospective cohort study

Endpoint

rsID

Gene

RA

EA

All ages

Age < 65 years

aOR

95% CI

P value

aOR

95% CI

P value

Rapid deterioration in CXR findings

rs60200309

DOCK2

G

A

1.47

0.95–2.27

0.084

1.73

0.97–3.07

0.061

 

rs1886814

FOXP4

A

C

1.31

0.95–1.79

0.094

1.09

0.70–1.69

0.711

 

rs72711165

TMEM65

T

C

1.27

0.60–2.68

0.538

0.82

0.28–2.44

0.723

 

rs6020298

TMEM189-UBE2V1

G

A

0.88

0.67–1.18

0.401

0.74

0.48–1.14

0.170

 

rs529565

ABO

T

C

1.67

1.23–2.26

< 0.001

1.91

1.25–2.94

0.003

 

rs77534576

TAC4

C

T

1.32

0.70–2.51

0.391

1.19

0.50–2.80

0.699

 

rs2109069

DPP9

G

A

1.13

0.73–1.74

0.589

1.19

0.66–2.14

0.570

 

rs13050728

IFNAR2

T

C

0.78

0.57–1.07

0.119

0.77

0.50–1.18

0.228

 

rs12252

IFITIM3

A

G

1.01

0.72–1.42

0.969

1.50

0.92–2.45

0.108

 

rs429358

APOE

T

C

1.37

0.88–2.15

0.168

1.65

0.92–2.95

0.092

 

rs12329760

TMPRSS2

C

T

0.88

0.64–1.21

0.429

1.02

0.66–1.58

0.914

 

rs2271616

SLC6A20

G

T

1.10

0.70–1.71

0.679

0.82

0.42–1.62

0.575

 

rs10774671

OAS1

G

A

0.89

0.62–1.27

0.519

0.89

0.54–1.49

0.666

 

rs4801778

PLEKHA4

G

T

1.20

0.50–2.90

0.681

2.18

0.60–7.99

0.238

 

rs11919389

None

T

C

1.19

0.88–1.59

0.263

1.13

0.74–1.73

0.570

  1. The adjusted odds ratio was estimated by logistic regression, with adjustment for age and sex.
  2. The odds ratio represents the incremental odds for each unit increase in allele dosage.
  3. The significance threshold based on Bonferroni’s correction was set at p < 0.0033.
  4. 95% CI, 95% confidence interval; aOR, adjusted odds ratio; EA, effect allele; RA, reference allele; COVID-19, coronavirus disease; CXR, chest X-ray.
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