Figure 1 | Scientific Reports

Figure 1

From: PI3K/Akt signaling pathway mediates the effect of low-dose boron on barrier function, proliferation and apoptosis in rat intestinal epithelial cells

Figure 1

The effects of boron on tight junction protein secretion in rat IEC-6 cells before and after PI3K/Akt inhibition. ELISA was used to analyze the effect of boron on secretion of ZO-1 and Occludin in IEC-6 cells before and after PI3K and Akt were inhibited by LY294002 and MK2206 2HCL, respectively. (A,B): IEC-6 cell culture medium was supplemented with 0, 0.8, 40 mmol/L boron and 10 μmol/L LY249002, respectively; (C,D): IEC-6 cell culture medium was supplemented with 0, 0.8, 40 mmol/L boron and MK2206 2HCL of 10 μmol/L, respectively; Values are presented as the mean ± SD; Mean values with asterisk (*) differed significantly (p < 0.05), mean values with two asterisks (**) indicate extremely significant differences (p < 0.01).

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