Figure 1 | Scientific Reports

Figure 1

From: HBV-miR-3 is closely related to HBV replication and strongly predictive of HBeAg seroconversion in PegIFN-α treated patients

Figure 1

HBV biomarkers dynamic changes between the HBeAg seroconversion group and the Non-HBeAg seroconversion group. (A) Spearman correlation coefficient in the pairwise correlations between HBV-miR-3, HBV RNA, HBV DNA, HBsAg, and HBeAg at different time-points. (B) Relationship Between HBV-miR-3 and HBV Replication: HBV-miR-3, HBV DNA, and HBV pgRNA in HepG2 versus HepG2.2.15 cells and HepG2 cells versus HepG2 cells transfected with pHBV1.3 plasmid. (C) Dynamic changes of HBV-miR-3, HBV RNA, HBV DNA and HBeAg during PegIFN treatment. (D) Differences in HBV-miR-3 between the HBeAg seroconversion group and the Non-HBeAg seroconversion group at different time-points. (E) HBV-miR-threefold changes at 12, 24, and 36 weeks to baseline in HBeAg seroconversion and non-seroconversion groups.

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