Figure 3
From: Distribution of multi-level B cell subsets in thymoma and thymoma-associated myasthenia gravis
Links between tumor microenvironment and peripheral blood in thymoma-associated MG. Different B cell subsets existed in the peripheral blood of TMG patients, which may have a homing effect with thymoma TME under the action of cytokines. A germinal center-vascular-like structure existed in the thymoma TME, and memory B cells in peripheral blood were recruited to the TME, while a fraction of B cells that passed through the germinal center and under the helper activation of T cells differentiated into plasma cells for transport from the blood vessels to the periphery. The immune activity status of thymoma TME contributed to the generation of the immune inflammatory cascade of thymoma-associated MG from another perspective. Switched and non-switched memory B cells in peripheral blood had certain clinical guiding significance as new markers. Figure image created with BioRender.com.
