Figure 4

Kinetic parameter maps from a sporadic vestibular schwannoma patient imaged using the single, low GBCA dose interleaved HT-HS DCE-MRI protocol and full GBCA dose (FDHS) acquisition (A) Representative images from a patient with a large left sided sporadic VS imaged using the single-injection low-dose interleaved high-temporal and high-spatial resolution (HT-HS) DCE-MRI acquisition followed by a full dose high-spatial resolution (FDHS) acquisition. Kinetic maps derived using either the low-dose LEGATOS_LDHS method or the full dose LEGATOS_DICE method are shown. Note the increased vascularity around the tumour capsule, visible on both the high-spatial T2W DRIVE acquisition (voxel size = 0.5 × 0.5 × 0.5 × 0.5 mm³) and LEGATOS derived v_p parameter maps ×. (B) Scatterplots demonstrating that for all parameters there was a significant voxelwise correlation between the LEGATOS_LDHS and LEGATOS_DICE derived values (p < 0.001) for the tumour shown in panel A. The overall median voxelwise difference (median % difference) for each of the LEGATOS_LDHS derived parameters with respect to LEGATOS_DICE estimates was− 0.01 (2.26%),− 0.10 min⁻¹ (− 39.2%) and− 0.02 (− 30.0%) for v_e, K^trans and v_p, respectively. For all parameters, the difference/bias in voxelwise LEGATOS_LDHS estimates increased with increasing voxel values (p < 0.001) with regions of high K^trans and v_p on the LEGATOS_DICE maps showing correspondingly lower LEGATOS_LDHS derived parameter values.