Figure 7
From: OPN silencing reduces hypoxic pulmonary hypertension via PI3K-AKT-induced protective autophagy
The effect of OPN knockdown in a hypoxic environment on RVHI, mPAP, and pathologic changes in the pulmonary arteries in HPH. (A) The intersecting gene between the top 10 DEGs and the hub genes was SPP1. (B) mPAP measurement. (C) RVHI measurement. (D) Sections of an electron microscope (scale bar: 1 µm) revealed altered pulmonary artery vascular cells. Mi (mitochondrion), N (nucleus), RER (rough endoplasmic reticulum). Pulmonary artery endothelial cells (red up arrow), pulmonary artery smooth muscle cells (yellow up arrow), autophagy (green up arrow). Results are representative of 7 independent experiments. Asterisks indicate statistically significant differences. *p < 0.05, **p < 0.01, ***p < 0.001.
