Figure 2
From: Expression and potential molecular mechanism of TOP2A in metastasis of non-small cell lung cancer
Effect of TOP2A on progression and metastasis of NSCLC. (A) A549 and H1299 cells were engineered to produce TOP2A-expressing and knockdown cell lines. (B) Wound healing experiment to evaluate the migratory capability of cells overexpressing or silencing TOP2A. (C) Transwell assays evaluated migratory and infiltration capacities of cells with TOP2A overexpression or silencing. (D) The correlation between TOP2A expression and tumor stage was analyzed based on TCGA data set. *P < 0.05, **P < 0.01, or ***P < 0.001. All experiments were repeated three times independently.
