Figure 6 | Scientific Reports

Figure 6

From: Mitochondrial division inhibitor (mdivi-1) induces extracellular matrix (ECM)-detachment of viable breast cancer cells by a DRP1-independent mechanism

Figure 6

Model of detachment of viable human breast cancer cells induced by mdivi-1. The inhibition of mitochondrial complex I by mdivi-1 triggers the detachment of viable breast cancer cells. These cells maintain their proliferative, migratory, and invasive potential once re-seeding. The effect of mdivi-1 on the cell detachment is independent of DRP1 but dependent on the pentose phosphate pathway (PPP) upon complex I inhibition OM: Outer Mitochondrial Membrane, IS: Intermembrane Space, IM: Inner Mitochondrial Membrane, MM: Mitochondrial Matrix, I: Mitochondrial complex I. (Created with BioRender.com).

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