Figure 4 | Scientific Reports

Figure 4

From: Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants

Figure 4

Analysis of cytokines and lung function. (a) Lung compliance was calculated for all patients. For analysis of survivors and non-survivors (left and middle graph) a Friedmann test or for the comparison of survivor to non-survivor (right graph) a one-way ANOVA Kurskal-Wallis followed by Dunn’s correction was performed. Box plots show the median of each group and the 10–90 percentile. Dot plots show the individual values of each patient (red = survivor, blue = non-survivor). The dotted line indicates 50 ml/cmH2O which is the lung compliance of a healthy individual. (b) Heatmap of Spearman correlation analysis of cytokines to the PaO2/FiO2 ratio at 6h post intubation. Red indicates positive correlation, blue negative correlation. (c) Individual correlation plot of PaO2/FiO2 ratio at 6h post intubation to IL-10 and TNF-β concentrations in ICU survivor. ns = non-significant; * = p < 0.05; ** = p < 0.01;*** = p < 0.001; **** = p < 0.0001.

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